The expressions of C-reactive protein and macrophage colony-stimulating factor in gingival tissue of human chronic periodontitis with hypertension.
10.5051/jkape.2009.39.4.391
- Author:
Chul Woo KIM
1
;
Jin Woo PARK
;
Jo Young SUH
;
Je Yoel CHO
;
Jae Mok LEE
Author Information
1. Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, Korea. leejm@knu.ac.kr
- Publication Type:Original Article
- Keywords:
chronic periodontitis;
C-reactive protein;
hypertension;
macrophage colony-stimulating factor
- MeSH:
Blotting, Western;
Bone Resorption;
C-Reactive Protein;
Chronic Periodontitis;
Gingiva;
Humans;
Hypertension;
Inflammation;
Macrophage Colony-Stimulating Factor;
Macrophages;
Proteins;
Tooth Extraction
- From:The Journal of the Korean Academy of Periodontology
2009;39(4):391-398
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to quantify and compare the expressions of CRP and M-CSF in the gingival tissues of the patients with chronic periodontitis associated to hypertension. METHODS: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. Clinically healthy gingival tissue samples from systemically healthy 12 patients were categorized as group 1 (n=12). Inflammatory gingival tissue samples from patients with chronic periodontitis were categorized as group 2 (n=12). Inflammatory gingival tissue samples from patients with chronic periodontitis associated with hypertension were categorized as group 3 (n=12). Tissue samples were prepared and analyzed by Western blotting. The quantification of CRP and M-CSF were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test. RESULTS: There were significant differences between group 1 and group 2 and between group 1 and group 3 in both CRP and M-CSF. The differences between group 2 and group 3 were not statistically significant in both proteins. However, the expression levels of CRP and M-CSF in hypertensive inflammatory gingiva showed increased tendency compared to non-hypertensive inflammatory gingiva. CONCLUSIONS: It is suggested that CRP and M-CSF might be used as inflammatory and bone resorption markers in periodontal diseased tissue. It is assumed that hypertension may be associated with the progression of periodontal inflammation and alveolar bone resorption.