Antibody Responses to Cryptosporidium Antigen in HIV-positive Patients in the Republic of Korea.
- Author:
Sang Mee GUK
1
;
Jong Yil CHAI
;
Yung Oh SHIN
;
Min SEO
Author Information
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords: Cryptosporidium parvum; serologic response; antigenic protein; HIV
- MeSH: AIDS-Related Opportunistic Infections/blood/*immunology; Adult; Aged; Animals; Antibodies, Protozoan/*blood/immunology; *Antibody Formation; Antigens, Protozoan/chemistry/*immunology; Blotting, Western/methods; Cryptosporidiosis/blood/*immunology; Feces/parasitology; Female; Humans; Korea; Male; Middle Aged; Protozoan Proteins/chemistry/immunology
- From:The Korean Journal of Parasitology 2008;46(2):71-75
- CountryRepublic of Korea
- Language:English
- Abstract: The diagnosis of cryptosporidiosis has been carried out using coprologic techniques in the Republic of Korea. However, antibody responses to Cryptosporidium have rarely been studied. Serum antibodies from HIV-positive/oocyst-positive Korean patients recognized significantly 31 and 27 kDa antigens, and HIV-negative/oocyst-positive individuals clearly reacted to 15/17 kDa antigens. Compared with oocyst-positive cases, 18.7% and 75.8% of sera from HIV-positive patients reacted to 31 and 27 kDa antigens. Only 11.1% of HIV-negative individuals reacted to 15/17 kDa. Based on these findings, serum antibody responses were different between HIV-positive and HIV-negative individuals infected with Cryptosporidium, and it is suggested that HIV-positive patients are more frequently exposed to C. parvum compared to HIV-negative individuals.
