A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry.
10.3346/jkms.2010.25.3.476
- Author:
Satoru JOSHITA
1
;
Koh NAKAZAWA
;
Shoichiro KOIKE
;
Atsushi KAMIJO
;
Kiyoshi MATSUBAYASHI
;
Hideharu MIYABAYASHI
;
Kiyoshi FURUTA
;
Kiyoshi KITANO
;
Kaname YOSHIZAWA
;
Eiji TANAKA
Author Information
1. Department of Internal Medicine, Matsumoto Medical Center, Matsumoto, Japan. joshita@shinshu-u.ac.jp
- Publication Type:Case Reports
- Keywords:
G-CSF-producing Tumor;
Carcinoma, Hepatocellular, Immunohistochemistry
- MeSH:
Aged;
Bone Neoplasms/secondary;
Carcinoma, Hepatocellular/*metabolism/pathology;
Fatal Outcome;
Granulocyte Colony-Stimulating Factor/*metabolism;
Humans;
Liver Neoplasms/*metabolism/pathology;
Male;
Receptors, Granulocyte Colony-Stimulating Factor/metabolism
- From:Journal of Korean Medical Science
2010;25(3):476-480
- CountryRepublic of Korea
- Language:English
-
Abstract:
Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing malignant tumors have been published, but scarcely any in the hepatobiliary system, such as in hepatocellular carcinoma (HCC). Here, we encountered a 69-yr-old man with a hepatic tumor who had received right hepatic resection. He showed leukocytosis of 25,450/microL along with elevated serum G-CSF. Histological examination of surgical samples demonstrated immunohistochemical staining for G-CSF, but not for G-CSF receptor. The patient survived without recurrence for four years, but ultimately passed away with multiple bone metastases. In light of the above, clinicians may consider G-CSF-producing HCC when encountering patients with leukocytosis and a hepatic tumor. More cases are needed to clarify the clinical picture of G-CSF-producing HCC.
