Primary T-cell Lymphoma of the Thyroid Associated with Hashimoto's Thyroiditis, Histologically Mimicking MALT-Lymphoma.
10.3346/jkms.2010.25.3.481
- Author:
Na Rae KIM
1
;
Young Hyeh KO
;
Young Don LEE
Author Information
1. Department of Pathology, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
- Publication Type:Case Reports
- Keywords:
Lymphoma, T-Cell;
Thyroid Gland;
T-Lymphocytes, Cytotoxic;
Lymphoma, B-Cell, Marginal Zone
- MeSH:
Female;
Hashimoto Disease/*pathology;
Humans;
Lymphoma, B-Cell, Marginal Zone/*pathology;
Lymphoma, T-Cell/*pathology;
Middle Aged;
T-Lymphocyte Subsets/immunology/pathology;
T-Lymphocytes, Cytotoxic/immunology/pathology;
Thyroid Gland/*pathology
- From:Journal of Korean Medical Science
2010;25(3):481-484
- CountryRepublic of Korea
- Language:English
-
Abstract:
Most of thyroid lymphomas are B-lineage, and T-cell lymphomas are rare. Here, we report a case of primary thyroid T-cell lymphoma associated with Hashimoto's thyroiditis. A 48-yr-old woman presented with incidentally found neck mass. Histologically, the resected right lobe of the thyroid was replaced by monomorphic small atypical lymphoid cells with lymphoepithelial lesion-like change, most of which were immunoreactive for CD3, CD8, betaF-1, and TIA-1. Peripheral T-cell lymphoma, unspecified, was finally diagnosed after molecular study for TCR-gamma gene rearrangement. This is the second case of cytotoxic T-cell lymphoma reported in the thyroid gland so far. Unique association between thyroid follicles and neoplastic lymphocytes may be characteristic feature of this type of T-cell lymphoma.
