A Case Report with Plasmablastic Lymphoma of the Jejunum.
10.3346/jkms.2010.25.3.496
- Author:
Jae Myung CHA
1
;
Joung Il LEE
;
Kwang Ro JOO
;
Sung Won JUNG
;
Hyun Phil SHIN
;
Jae Jin LEE
;
Gyo Young KIM
Author Information
1. Department of Internal Medicine, University of Kyunghee College of Medicine, Seoul, Korea. dramc@hanmail.net
- Publication Type:Case Reports
- Keywords:
HIV-negative;
Jejunum;
Plasmablastic Lymphoma
- MeSH:
Diagnosis, Differential;
Humans;
Immunophenotyping;
Jejunal Neoplasms/immunology/*pathology/therapy;
Jejunum/immunology/*pathology;
Lymphoma, Large-Cell, Immunoblastic/immunology/*pathology/therapy;
Male;
Middle Aged
- From:Journal of Korean Medical Science
2010;25(3):496-500
- CountryRepublic of Korea
- Language:English
-
Abstract:
Plasmablastic lymphoma (PBL) is a recently identified entity that is considered to be a type of diffuse large B-cell lymphoma with a unique immunophenotype and a predilection for the oral cavity of patients with the human immunodeficiency virus (HIV). Although its clinical features may help in the differential diagnosis, an extraoral location in a patient without HIV makes it more difficult to suspect clinically. This case report is the first to describe a patient with PBL originating from the jejunum in a 60-yr-old, HIV-seronegative man. Computed tomography of the face, chest and abdomen showed about a 9.4x9.0 cm mass of the proximal jejunum, multiple masses in the musculoskeletal soft tissue, and multiple lymphadenopathies. The histological examinations demonstrated a large cell lymphoma with plasmablastic differentiation. The neoplastic cells were diffusely positive for MUM1, epithelial membrane antigen and lambda light chains, and focally positive for CD79a; but negative for CD3, CD20, CD30, CD34, CD45RO, CD56, CD99, and CD117. The proliferation index by Ki-67 immunohistochemistry was approximately 70%. These findings were compatible with the diagnosis of PBL. The findings in this case suggest that PBL should be included in the differential diagnosis of a small bowel mass even in a HIV-negative patient.
