A Case of Central Pontine and Extrapontine Myelinolysis in a Patient with Maintenance Hemodialysis.
- Author:
Sung Won JANG
1
;
Il Young KIM
;
Jung Hee KIM
;
Sang Heon SONG
;
Dong Won LEE
;
Soo Bong LEE
;
Sung Joo LEE
;
Ihm Soo KWAK
Author Information
1. Department of Internal Medicine, Pusan National University, College of Medicine, Busan, Korea. sbleemd@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Myelinolysis;
Central pontine;
Renal dialysis;
Magnetic resonance imaging
- MeSH:
Alcoholism;
Brain;
Cellulitis;
Consciousness;
Diabetes Mellitus, Type 2;
Dysarthria;
Humans;
Hyponatremia;
Magnetic Resonance Imaging;
Male;
Middle Aged;
Myelinolysis, Central Pontine*;
Nausea;
Osmolar Concentration;
Outpatients;
Pons;
Pseudobulbar Palsy;
Quadriplegia;
Renal Dialysis*;
Sodium;
Tegmentum Mesencephali;
Vomiting
- From:Korean Journal of Nephrology
2006;25(2):327-331
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) is a rare syndrome that is clinically characterized by quadriparesis, pseudobulbar palsy, and disturbance of consciousness. It commonly occurs in patients with rapid correction of hyponatremia and chronic alcoholism. We report a case of CPM and EPM in a 55-year-old male patient with maintenance hemodialysis. He had type 2 diabetes mellitus for more than 20 years and underwent hemodialysis for the past 7 months. He was admitted for left periorbital cellulitis and uremic symptoms. On the 34th hospital day, he had nausea, vomiting, decreased consciousness, dysarthria and quadriparesis. Laboratory data were revealed as follows:glucose, 117 mg/dL; sodium, 137.1 mEq/L; and serum osmolality, 277 mosm/L. Magnetic resonance imaging (MRI) of the brain revealed increased signal intensity in the pons, upper medulla, cerebellar peduncle and cerebral peduncle in T2 weighted images. This case was considered as primary CPM and EPM occurring in a patient with maintenance hemodialysis. With general supportive care, the patient has been recovered gradually and is being followed up on an outpatient basis.
