Monocyte Chemoattractant Protein-1(MCP1)-2518 Polymorphism and Major Depressive Disorder.
- Author:
Chi Un PAE
1
;
Ji Hyun LEE
;
Yoon Kyung SHIN
;
Tae Suk KIM
;
Jung Jin KIM
;
Chang Uk LEE
;
Soo Jung LEE
;
Tae Youn JUN
;
Chul LEE
;
In Ho PAIK
Author Information
1. Department of Psychiatry, Kangnam St. Mary's Hospital, Korea. knpsy@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Major depressive disorder;
MCP1 -2518 polymorphism;
Korean
- MeSH:
Alleles;
Chemokine CCL2;
Depressive Disorder, Major*;
Genotype;
Humans;
Monocytes*
- From:Journal of Korean Neuropsychiatric Association
2004;43(4):381-385
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECT: This study was designed to examine the association between monocyte chemoattractant protein-1 (MCP1) -2518 polymorphism and major depressive disorder (MDD). METHODS: Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: Genotype and allele distributions in patients with MDD were significantly different from those of the controls. In particular, subjects with the allele A were found to have an increased risk of MDD. CONCLUSION: The present study suggests that the MCP1 -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.
