The Study of Intraocular Vascular Endothelial Growth Factor Concentration in Diabetic Retinopathy after Panretinal Photocoagulation.
- Author:
Suk Dong KIM
1
;
Jong Min KIM
;
Dong Peal LEE
Author Information
1. Dapartment of Ophthalmology, Holy Family Hospital, The Catholic University Medical College.
- Publication Type:Original Article
- Keywords:
Proliferative diabetic retinopathy;
Panretinal photocoagulation;
Vascular endothelial growth factor
- MeSH:
Aqueous Humor;
Cataract;
Diabetic Retinopathy*;
Humans;
Light Coagulation*;
Vascular Endothelial Growth Factor A*
- From:Journal of the Korean Ophthalmological Society
1999;40(12):3384-3389
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vascular endothelial growth factor[VEGF] might play important roles in angiogenesis of diabetic retinopathy. Aim of this study is to determine the effect of panretinal photocoagulation[PRP] on the level of VEGF in intraocular fluid of proliferative diabetic retinopathy[PDR]. Aqueous humor was obtained during cataract surgery from 35 eyes of 35 patients with PDR and VEGF concentration was measured using enzyme-linked immunosorbent assay[ELISA]. Patients were classified into 4 groups according to total amount of panretinal photocoagulation[PRP][group A:no PRP, group B: less than 1000 spots, group C: 1000~1500 spots, group D: more than 1500 spots] and VEGF level was analyzed in each group using Spearman's correlation coefficient by rank. Mean concentration of VEGF is 615pg/mlin group A, 307pg/mlin group B, 234 pg/mlin group C, and 136pg/mlin group D. The level of VEGF was significantly lower as total amount of PRP increased[p<0.05]. These findings suggest that therapeutic effect of PRP on PDR can be explained by the reduction of VEGF concentration in intraocular fluid.
