Unusual Manifestation of Intravascular Large B-Cell Lymphoma: Severe Hypercalcemia with Parathyroid Hormone-Related Protein.
- Author:
Jung Min HA
1
;
Eun KIM
;
Woo Joo LEE
;
Ji Won HWANG
;
Sehyo YUNE
;
Young Hyeh KO
;
Joon Young CHOI
;
Seok Jin KIM
;
Won Seog KIM
Author Information
1. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kstwoh@skku.edu
- Publication Type:Case Report
- Keywords:
Intravascular lymphoma;
Hypercalcemia;
Parathyroid hormone-related protein
- MeSH:
Aged;
Bone Marrow;
Bone Marrow Examination;
Diagnosis, Differential;
Drug Therapy;
Early Diagnosis;
Electrons;
Fever;
Humans;
Hypercalcemia*;
Lymphatic Diseases;
Lymphoma, B-Cell*;
Lymphoma, Non-Hodgkin;
Male;
Parathyroid Hormone-Related Protein*;
Spleen
- From:Cancer Research and Treatment
2014;46(3):307-311
- CountryRepublic of Korea
- Language:English
-
Abstract:
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin lymphoma. It usually presents with nonspecific symptoms, such as fever, rather than with overt lymphadenopathy. Reports of hypercalcemia, as the initial presentation of IVLBCL, are limited in the literature, despite it being a well-known complication of various solid cancers. We present a 68-year-old male with severe hypercalcemia and increased levels of serum parathyroid hormone-related protein. He was diagnosed with IVLBCL, involving the bone marrow and spleen, and was successfully treated with rituximab-containing chemotherapy. A few previous case reports have shown hypercalcemia in patients with IVLBCL. Much like our case, previous cases with hypercalcemia had advanced diseases, including bone marrow invasion. Although it was an extremely rare manifestation of IVLBCL, we suggest that IVLBCL should be a part of the differential diagnosis in patients with unexplained hypercalcemia. Therefore, an active work-up might be recommended, including positron emission tomography/computed tomography scan and bone marrow examination, which may be useful for early diagnosis.
