Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study.
- Author:
Bok Ki JUNG
1
;
Won Jai LEE
;
Eunhye KANG
;
Hyo Min AHN
;
Yong Oock KIM
;
Dong Kyun RAH
;
Chae Ok YUN
;
In Sik YUN
Author Information
- Publication Type:Original Article
- Keywords: Gene therapy; Cicatrix; Relaxin; Adenovirus
- MeSH: Adenoviridae*; Cicatrix*; Genetic Therapy; Pliability; Relaxin*; Swine; Therapeutic Uses; Transforming Growth Factors
- From:Archives of Craniofacial Surgery 2017;18(1):9-15
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. METHODS: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. RESULTS: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. CONCLUSION: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
