The Effect of Anti-reflux Therapy on Patients Diagnosed with Minor Disorders of Peristalsis in High-resolution Manometry.
10.4166/kjg.2017.69.4.212
- Author:
Joonho JEONG
1
;
Sung Eun KIM
;
Moo In PARK
;
Seun Ja PARK
;
Won MOON
;
Jae Hyun KIM
;
Kyoungwon JUNG
;
Youn Jung CHOI
;
Jun Yeob LEE
;
Young Dal LEE
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. solefide@hanmail.net
- Publication Type:Original Article
- Keywords:
Esophageal motility disorders;
Manometry;
Treatment outcome;
Proton pump inhibitors
- MeSH:
Classification;
Esophageal Motility Disorders;
Follow-Up Studies;
Gastroesophageal Reflux;
Humans;
Manometry*;
Medical Records;
Peristalsis*;
Prospective Studies;
Proton Pump Inhibitors;
Proton Therapy;
Treatment Outcome
- From:The Korean Journal of Gastroenterology
2017;69(4):212-219
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy in patients with minor peristaltic disorders. METHODS: Patients with minor peristaltic disorders in accordance with CC v3.0 were included. We reviewed the medical records of patients with esophageal high-resolution manometry findings, and investigated the demographic and clinical information as well as the medical therapy. Thereafter, the response to treatment was assessed after at least 4 weeks of treatment. RESULTS: A total of 24 patients were identified as having minor disorders of peristalsis from January 2010 to December 2015. The mean follow-up period was 497 days, and there were 17 patients (70.8%) patients with ineffective esophageal motility. In terms of anti-reflux therapy, proton pump inhibitors (PPIs) with prokinetic agents and PPIs alone were prescribed in 19 patients (79.2%) and 5 patients (20.8%), respectively. When the rate of response to the treatment was assessed, the responders rate (complete+satisfactory [≥50%] responses) was 54.2% and the non-responders rate (partial [<50%]+refractory responses) was 45.8%. Patients in the responder group were younger than those in the non-responder group (p=0.020). Among them, 13 patients underwent 24-hour multichannel intraluminal impedance-pH, and 10 patients (76.9%) were pathologic gastroesophageal reflux. CONCLUSIONS: The majority of esophageal minor peristaltic disorders were accompanied by gastroesophageal reflux, and therefore, they might respond to acid inhibitor. Further well-designed, prospective studies are necessary to confirm the effect of anti-reflux therapy in these patients.
