Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg).
- Author:
Joonyong NOH
1
;
Wahn Soo CHOI
;
Geunwoong NOH
;
Jae Ho LEE
Author Information
- Publication Type:Brief Communication
- Keywords: Foxp3; Regulatory B cell; Breg; CD5; CD19; CD5(+) B
- MeSH: Apoptosis; B-Lymphocytes; B-Lymphocytes, Regulatory; Humans; T-Lymphocytes, Regulatory
- From:Immune Network 2010;10(6):247-249
- CountryRepublic of Korea
- Language:English
- Abstract: Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of 8.5+/-3.5% of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
