Treatment of Intravenous Immune-Globulin Resistant Kawasaki Disease with Corticosteroids.
- Author:
Dae Eui HONG
1
;
Kyung Yil LEE
;
Ji Whan HAN
;
Sung Soo HWANG
;
Kyong Su LEE
Author Information
1. Department of Pediatrics, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Kawasaki disease;
Methylprednisolone therapy;
Intravenous immune globulin
- MeSH:
Adrenal Cortex Hormones*;
Aneurysm;
Arteries;
Child;
Coronary Vessels;
Echocardiography;
Fever;
Humans;
Immunoglobulins, Intravenous;
Methylprednisolone;
Mucocutaneous Lymph Node Syndrome*;
Prednisolone;
Retreatment
- From:Journal of the Korean Pediatric Society
1997;40(10):1453-1457
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the efficacy of steroid therapy on prevention of development and progression of coronary artery aneurysm in intravenous immune globulin (IVIG)-resistant Kawasaki disease, we treated three children with high dose of intravenous methylprednisolone followed by low dose oral prednisolone. METHODS: We selected three children with Kawasaki disease who did not repond or who initially responded but soon developed recrudescent fever after retreatment of IVIG (total 4gm/kg). These three patients were treated with high dose methylprednisolone (10mg/kg) intravenously and followed by low dose prednisolone (1mg/kg) orally for 7 days. Echocardiographic evalutions were performed within 8 days of admission (before steroid therapy), at discharge and 1 month after discharge. RESULTS: All three patients showed rapid normalization of clinical symptoms and did not developed significant coronry artery abnormalities. No adverse reaction was observed. CONCLUSIONS: Steroid therapy (mini pulse methylprednisolone and prednisolone therapy) is valuable for patients with Kawasaki disease resistant to intravenous immune globulin therapy.
