Clinical Usefulness between High Dose Radioiodine Therapy and Helicobacter Pylori Infection after Total Thyroidectomy due to Well Differentiated Thyroid Cancer.
- Author:
Kuk No YUN
1
;
Seok Tae LIM
;
Eun Ha MOON
;
Jin Suk KIM
;
Young Jin JEONG
;
Dong Wook KIM
;
Hwan Jeong JEONG
;
Myung Hee SOHN
Author Information
1. Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea. stlim@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Radioiodine therapy;
urea breath test;
well differentiated thyroid cancer;
Helicobacter pylori
- MeSH:
Breath Tests;
Dyspepsia;
Follow-Up Studies;
Gastritis;
Helicobacter;
Helicobacter pylori;
Humans;
Peptic Ulcer;
Salivary Glands;
Stomach;
Thyroid Gland;
Thyroid Neoplasms;
Thyroidectomy;
Urea
- From:Nuclear Medicine and Molecular Imaging
2009;43(6):572-576
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Helicobacter (H) pylori infection has been considered the most important cause of gastritis, dyspepsia, and gastroduodenal ulcer. Radioiodine can be accumulated in the remaining thyroid tissue, salivary gland, and stomach. We investigated if the high radiation induced by radioiodine in the stomach after high dose radioiodine therapy (HD-RIT) is effective in the eradication of H. pylori infection. MATERIALS AND METHODS: One hundred ninety nine patients (M:F=33:166, age 46.7+/-12.3 years) who had HD-RIT (dose 159.1+/-25.9 mCi, range 120-250 mCi) after thyroidectomy due to well differentiated thyroid cancer were enrolled. To detect H. pylori infection, the urea breath tests (UBT) were performed at 1 hour before HD-RIT and at 4 weeks after HD-RIT. The results of UBT were classified as positive (> or =50 dpm) or negative (<50 dpm), and analyzed its values. RESULTS: Of 199 patients, 103 (51.8%) patients had positive UBT before HD-RIT. Of these, 80 patients had follow-up UBT after HD-RIT. Among them, 76 (95.0%) patients had persistent positive UBT and only 4 (5.0%) patients were changed negative UBT. Among 76 patients with persistent positive UBT, 26 (34.2%) patients had increased the values of follow-up UBT, 49 (64.5%) had decreased them, and 1 (1.3%) had shown the same value. The different values of UBT between before and after HD-RIT were 62+/-66.1 dpm in increased one of follow-up UBT, and 153.3+/-157.1 dpm in decreased one of follow-up UBT. CONCLUSION: We conclude that the radiation induced by HD-RIT is ineffective in the eradication of H. pylori infection. However, it could be influential the degree or distribution of H. pylori infection.
