Granular Cell Tumor of the Descending Colon Treated by Endoscopic Mucosal Resection: A Case Report and Review of the Literature.
10.3346/jkms.2009.24.2.337
- Author:
Jae Myung CHA
1
;
Joung Il LEE
;
Kwang Ro JOO
;
Jae Won CHOE
;
Sung Won JUNG
;
Hyun Phil SHIN
;
Sung Jik LIM
Author Information
1. Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea. dramc@hanmail.net
- Publication Type:Case Report ; Review
- Keywords:
Colon;
Neoplasms;
Endoscopic Mucosal Resection;
Granular Cell Tumor;
Submucosal Tumor
- MeSH:
Adult;
*Colon, Descending/pathology;
Colonic Neoplasms/diagnosis/*pathology/surgery;
Colonoscopy;
Diagnosis, Differential;
Granular Cell Tumor/diagnosis/*pathology/surgery;
Humans;
Male;
S100 Proteins/metabolism
- From:Journal of Korean Medical Science
2009;24(2):337-341
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although colorectal granular cell tumors (GCTs) are rare, their incidental finding has increased as the use of diagnostic colonoscopy has become more common. Here we describe the case of a 41-yr-old man with a GCT in the descending colon that was detected after a screening colonoscopy. Endoscopic examination revealed a yellowish submucosal tumor, 13x12 mm in diameter, in the descending colon. Endoscopic mucosal resection (EMR) followed by histological examination revealed that the tumor was composed of plump histiocyte-like cells with an abundant granular eosinophilic cytoplasm and small round nuclei. The tumor cells expressed S-100 protein and stained with periodic acid-Schiff, but were negative for desmin and cytokeratin. The resected tumor was diagnosed as a GCT. Colonoscopists should consider the possibility of GCT in the differential diagnosis of yellowish submucosal tumors of the colon. In such patients, EMR seems to be a feasible and safe approach for diagnosis and treatment.
