Expressions and Clinical Significances of Angiopoietin-1, Angiopoietin-2, and Tie-2 Receptor in Patients With Colorectal Cancer.
- Author:
Sunghoon HONG
1
;
Hae Il JUNG
;
Tae Sung AHN
;
Han Jo KIM
;
Kyu Taek LEE
;
Moo Jun BAEK
;
Sang Byung BAE
Author Information
- Publication Type:Original Article
- Keywords: Colorectal neoplasms; Angiopoietins; TIE-2 receptor; Prognosis
- MeSH: Angiopoietin-1*; Angiopoietin-2*; Angiopoietins; Blotting, Western; Colorectal Neoplasms*; Humans; Immunohistochemistry; Neoplasm Metastasis; Prognosis; Receptor, TIE-2*; Retrospective Studies
- From:Annals of Coloproctology 2017;33(1):9-15
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Angiopoietin-1 (Ang-1) plays a crucial role in vascular and hematopoietic development, mainly through its cognate receptor, Tie-2. Increased levels of Ang-2 have been shown to be correlated with abnormal tumor angiogenesis in several malignancies. Hence, we estimated the increased expression of Ang-2 relative to Ang-1 in patients with colorectal cancer and correlated our finding with prognosis in order to investigate the relationships between the expressions of Ang-1/Ang-2/Tie-2 receptor and the clinical parameters or overall survival of such patients. METHODS: We retrospectively analyzed 114 tissue samples from patients with colorectal cancer by using immunohistochemistry (IHC) to examine Ang-1, Ang-2, and Tie-2 expressions and to investigate the relationship between those expressions and clinical parameters or overall survival of such patients. A Western blot analysis was used for Ang-2 expression. RESULTS: IHC staining showed a link between Ang-1 and Tie-2 (P = 0.018), as well as meaningful correlations between Ang-2 and Tie-2 receptor (P = 0.022) and between lymph-node metastasis and Ang-2 (P = 0.025). The stronger the IHC staining for Ang-2 expression was, the shorter the cumulative survival was (P = 0.016). CONCLUSION: A relationship was found to exist between Ang-2 and Tie-2 expressions. The Ang-2 was correlated with lymph-node metastasis, and high expression of Ang-2 was indicative of poor overall survival. These findings suggest that Ang-2 is a useful prognostic marker in the management of patients with colorectal cancer. In addition, we suggest that Ang/Tie-2 signaling plays an important role in the progression of colorectal cancer.
