A Case of Multiple Thromboembolisms in Hyperhomocysteinemia.
10.4046/trd.1999.47.2.239
- Author:
Jae Sun PARK
1
;
Won Ki BAE
;
Sang Jun LEE
;
Rae In CHUNG
;
Seong Lim JIN
;
Hyuk Pyo LEE
;
Joo In KIM
;
Soo Jeon CHOI
;
Ho Kee YUM
Author Information
1. Department of Internal Medicine, College of Medicine, Inje University, Seoul, Korea. hhokee @ unitel. co.kr
- Publication Type:Case Report
- Keywords:
Hyperhomocysteinemia;
Thromboembolisms
- MeSH:
Atherosclerosis;
Brain;
Endothelial Cells;
Endothelium, Vascular;
Humans;
Hyperhomocysteinemia*;
Korea;
Lower Extremity;
Metabolism;
Peripheral Vascular Diseases;
Plasma;
Risk Factors;
Stroke;
Thromboembolism*;
Veins;
Vitamins
- From:Tuberculosis and Respiratory Diseases
1999;47(2):239-246
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperhomocysteinemia is an independent risk factor for cardiovascular, cerebrovascular and peripheral vascular diseases complicated with atherosclerosis and thromboembolism. Increased plasma homocystein level develops from genetic defect of enzyme for homocystein metabolism or vitamine deficiency, has direct toxic effect for vascular endothelium and makes damages to antithrombotic action of vascular endothelial cell. Most of hyper-homocysteinemia is asymptomatic, but rarely develops cardiopulmonary or cerebrovascular accidents. In case of thromboembolism with unknown cause, the hyperhomocysteinemia should be considered as one of the many etiologies. The authors, first in korea, report a case of multiple thromboembolisms of deep vein of lower extremity, pulmonary vessels, superior sagittal and transverse sinus of brain in a patient with the hyperhomocysteinemia with a review of literature.
