Chemical Constituents of Fermented Noni (Morinda citrifolia) Juice Exudates and Their Biological Activity.
10.20307/nps.2017.23.1.16
- Author:
Ui Joung YOUN
1
;
Leng Chee CHANG
Author Information
1. Division of Life Sciences, Korea Polar Research Institute, KIOST, Incheon, 21990, Republic of Korea. ujyoun@kopri.re.kr
- Publication Type:Original Article
- Keywords:
Morinda citrifolia;
Rubiaceae;
alkyl disaccharide;
phenyl ethandiol;
anti-inflammatory activity
- MeSH:
Exudates and Transudates*;
Morinda*;
Nitric Oxide;
Plants;
Rubiaceae;
Tumor Necrosis Factor-alpha
- From:Natural Product Sciences
2017;23(1):16-20
- CountryRepublic of Korea
- Language:English
-
Abstract:
In a continuing study of the fermented noni (Morinda citrifolia) juice exudates, five compounds, heptanyl 2-O-β-D-xylofuranosyl-(1 → 6)-β-D-glucopyranoside (1), n-butyl β-D-glucopyranoside (2), (1S)-(3-ethenyl-phenyl)-1,2-ethanediol (3), (2S)-2-hydroxybutanedioic acid (4), and daucosterol (5) were isolated from the buthanol partition of the extract. The structures of the isolates were identified by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with the published values. Among the isolates, compounds 1 – 3 were isolated for the first time from the plant species. The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor alpha (TNF-α)-induced NF-κB activity, and quinonone reductase-1 (QR1)-inducing effect.
