Anti-obesity Effect of Steamed Soybean and Fermented Steamed Soybean in High-fat Diet-induced Obese ICR Mice.
10.20307/nps.2017.23.1.61
- Author:
Hye Rin SEO
1
;
Ah Young LEE
;
Kye Man CHO
;
Eun Ju CHO
;
Hyun Young KIM
Author Information
1. Department of Food Science and Nutrition, Pusan National University, Busan 46241, Korea. ejcho@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Obesity;
Soybean;
High-fat diet;
Lipid metabolism;
Oxidative stress
- MeSH:
Alanine Transaminase;
Animals;
Aspartate Aminotransferases;
Body Weight;
Cholesterol;
Diet;
Diet, High-Fat;
Leptin;
Lipid Metabolism;
Lipid Peroxidation;
Liver;
Mice;
Mice, Inbred ICR*;
Mice, Obese;
Nitric Oxide;
Obesity;
Oxidative Stress;
Plasma;
Soybeans*;
Steam*;
Triglycerides
- From:Natural Product Sciences
2017;23(1):61-68
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was performed to investigate the ameliorating effects of steamed soybeans (SS) and fermented SS (FSS) on lipid metabolism in high-fat diet-induced obese mice. ICR mice were divided into four groups and given the following different diets: normal diet (ND), high-fat diet (HFD), HFD with 1% SS (HFD + SS), and HFD with 1% FSS (HFD + FSS). After 14 weeks, the body weight gain was higher in the HFD group compared with the ND group but lower in the HFD + FSS group compared with the HFD group. Plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly higher in the HFD group compared to the ND group, but lower in the HFD + SS and HFD + FSS groups compared with the HFD group. In addition, leptin concentration in plasma was lower in the groups fed HFD + SS and HFD + FSS compared with the HFD group. The accumulation of hepatic TG and TC was significantly inhibited in the HFD + SS and HFD + FSS groups. Furthermore, SS and FSS attenuated lipid peroxidation and nitric oxide formation in the liver induced by the high-fat diet. These results suggest that soybeans, especially FSS, may be useful in preventing obesity-induced abnormalities in lipid metabolism.
