Primary Malignant Melanoma of the Rectum.
- Author:
Seung Jae YOON
1
;
Yong Woon SHIN
;
Cheol Soon JANG
;
Byung Kwan CHO
;
Yong Bum CHO
;
Don LEE
;
Seong Ryul KWON
;
Hyun Suk KIM
;
Kye Sook KWON
;
Hyun Keun CHO
;
Pum Soo KIM
;
Young Soo KIM
;
Kyung Rae KIM
;
Soo Kee MIN
Author Information
1. Department of Internal Medicine, Inha University College of Medicine, Sungnam, Korea.
- Publication Type:Original Article
- Keywords:
Malignant melanoma
- MeSH:
Aged;
Anal Canal;
Female;
Hemorrhage;
Humans;
Larynx;
Liver;
Melanocytes;
Melanoma*;
Microscopy;
Mouth;
Mucous Membrane;
Neoplasm Metastasis;
Nose;
Pigmentation;
Prognosis;
Rectum*;
S100 Proteins;
Tomography, X-Ray Computed;
Vagina;
Vulva
- From:Journal of the Korean Society of Coloproctology
2000;16(6):478-482
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Malignant melanoma arising from the mucosal surface is a rare, virulent malignant neoplasm frequently associated with an extremely poor prognosis. The sites of initial presentation include the nose, oral cavity, larynx, vulva, vagina, anal canal and rectum. Primary melanoma of the rectum is extremely rare and its histogenesis is controversial. We present a case of primary malignant melanoma arising from the rectum in a 77-year-old woman who presented with intermittent anal bleeding for 2 months. Colonoscopic examination of the rectum revealed a 3.5 3.0 2.7 cm exophytic tumor with a granular surface in the rectum, 5cm from the anal verge. Black colored pigmentation was detected. Distant metastasis to liver was detected on abdominal CT scan. Light microscopy of tumor revealed malignant melanocytes surrounded by normal mucosa. The tumor cells reacted positively for immunohistochemical staining with S-100 protein and HMB-45. Clinical and laboratory examination excluded the presence of melanoma at sites other than rectum. Local excision of the tumor was performed.
