Metronidazole Resistance and the Eradication of Helicobacter pylori.
- Author:
Gwang Ho MUN
1
;
Joon Soo HAHM
;
Kwang Hyun RYU
;
Oh Young LEE
;
Dong Soo HAN
;
Byung Chul YOON
;
Ho Soon CHOI
;
Min Ho LEE
;
Choon Suhk LEE
;
Kyung Nam PARK
;
Jung Ok KANG
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine.
- Publication Type:Original Article
- Keywords:
Peptic ulcer;
Helicobacter pylori;
Metranidazole resistance
- MeSH:
Amoxicillin;
Bismuth;
Diffusion;
Helicobacter pylori*;
Helicobacter*;
Humans;
Korea;
Metronidazole*;
Peptic Ulcer
- From:Korean Journal of Gastrointestinal Endoscopy
1998;18(6):847-852
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The success of Helicobacter pylori eradication is limited by antibiotic resistances, and the primary resistance to metranidazole seems to be high. In this study, the frequency af metronidazole resistance and the eradication rate in metronidazole-resistant H. pylori strain was evaluated. METHODS: Sixty-eight patients were tested for metronidazole resistance using microdilution broth, the E test and disk diffusion method. Twenty-two patients were treated for 14 days with amoxicilline 2000 mg, metronidazole 750 mg, and tripotassium dicitrate bismuth 1200 mg. RESULTS: Metronida-zole resistance was 46% (31/68). The eradication rates for H. pylori was 91.7% in patients with metronidazole-sensistive strains and 70% in patients with metronidazole-resistant strains. CONCLUSIONS: Metronidazole resistance was high (46%) in Korea, however, triple therapy was an efficient method of eradicating H. pylori in both metronidazole sensitive and resistant strains.
