MRI Findings of Triple Negative Breast Cancer: A Comparison with Non-Triple Negative Breast Cancer.
10.13104/jksmrm.2010.14.2.95
- Author:
Jae Jeong CHOI
1
;
Sung Hun KIM
;
Eun Suk CHA
;
Bong Joo KANG
;
Ji Hye LEE
;
So Yeon LEE
;
Seung Hee JEONG
;
Hyeon Woo YIM
;
Byung Joo SONG
Author Information
1. Department of Radiology, College of Medicine, The Catholic University of Korea, Korea. rad-ksh@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Breast cancer;
Estrogen receptor;
Progesterone receptor;
HER2;
Magnetic resonance imaging (MRI)
- MeSH:
Breast;
Breast Neoplasms;
Humans;
Information Systems;
Magnetic Resonance Imaging;
Receptor, Epidermal Growth Factor;
Receptors, Progesterone;
Retrospective Studies
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2010;14(2):95-102
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the magnetic resonance imaging (MRI) and clinicopathological features of triple negative breast cancer, and compare them with those of non-triple negative breast cancer. MATERIALS AND METHODS: This study included 231 pathologically confirmed breast cancers from January 2007 to May 2008. We retrospectively reviewed the MRI findings according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon: mass or non-mass type, mass shape, mass margin, non-mass distribution, and enhancement pattern. Histologic type, histologic grade, and the results for epidermal growth factor receptor, p53, and Ki 67 were reviewed. RESULTS: Of 231 patients, 43(18.6%) were triple negative breast cancer. Forty triple negative breast cancers (93.0%) were mass-type lesion on MRI. A round or oval or lobular shape (p=0.006) and rim enhancement (p=0.004) were significantly more in triple negative breast cancer than non-triple negative breast cancer. In contrast, irregular shape (p=0.006) and spiculated margins (p=0.032) were significantly more in non-triple negative breast cancer. Old age (p=0.019), high histologic grade (p<0.0001), EGFR positivity (p<0.0001), p53 overexpression (p=0.038), and Ki 67 expression (<0.0001) were significantly associated with the triple negative breast cancer. CONCLUSION: MRI finding may be helpful for differentiation between triple negative and non-triple negative breast cancer.
