Low Frequency Fluctuation Component Analysis in Active Stimulation fMRI Paradigm.
10.13104/jksmrm.2010.14.2.115
- Author:
Sung Min NA
1
;
Hyun Jung PARK
;
Yongmin CHANG
Author Information
1. Department of Medical and Biological Engineering, Kyungpook National University, Korea.
- Publication Type:Original Article
- Keywords:
fMRI;
Active paradigm;
Spontaneous fluctuation;
ICA
- MeSH:
Cerebellum;
Echo-Planar Imaging;
Female;
Fingers;
Humans;
Magnetic Resonance Imaging;
Motor Cortex;
Oxygen
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2010;14(2):115-120
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To separate and evaluate the low frequency spontaneous fluctuation BOLD signals from the functional magnetic resonance imaging data using sensorimotor active task. MATERIALS AND METHODS: Twenty female archery players and twenty three control subjects were included in this study. Finger-tapping task consisted of three cycles of right finger tapping, with a subsequent 30 second rest. Blood oxygenation level-dependent (BOLD) data were collected using T2*-weighted echo planar imaging at a 3.0 T scanner. A 3-D FSPGR T1-weighted images were used for structural reference. Image processing and statistical analyses were performed using SPM5 for active finger-tapping task and GIFT program was used for statistical analyses of low frequency spontaneous fluctuation BOLD signal. RESULTS: Both groups showed the activation in the left primary motor cortex and supplemental motor area and in the right cerebellum for right finger-tapping task. ICA analysis using GIFT revealed independent components corresponding to contralateral and ipsilateral sensorimotor network and cognitive-related neural network. CONCLUSION: The current study demonstrated that the low frequency spontaneous fluctuation BOLD signals can be separated from the fMRI data using finger tapping paradigm. Also, it was found that these independent components correspond to spontaneous and coherent neural activity in the primary sensorimotor network and in the motor-cognitive network.
