Five-Year Follow-up Study of Monoclonal Gammopathy of Undetermined Significance in a Korean Elderly Urban Cohort.
- Author:
Yun Gyoo LEE
1
;
Soo Mee BANG
;
Jeong Ok LEE
;
Jin Won KIM
;
Keun Wook LEE
;
Jee Hyun KIM
;
Jung Han SONG
;
Tae Hee KIM
;
Ki Woong KIM
;
Jong Seok LEE
Author Information
- Publication Type:Original Article
- Keywords: Monoclonal gammopathy of undetermined significance; Prevalence; Follow-up studies
- MeSH: Aged*; Cohort Studies*; Electrophoresis; Follow-Up Studies*; Humans; Korea; Mass Screening; Monoclonal Gammopathy of Undetermined Significance*; Multiple Myeloma; Prevalence
- From:Cancer Research and Treatment 2015;47(2):215-220
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: We previously reported the prevalence of monoclonal gammopathy of undetermined significance (MGUS) to be 3.3% among an elderly Korean urban cohort recruited during 2005-2006. Here, we report a 5-year follow-up study of the previously identified MGUS cohort. MATERIALS AND METHODS: The 680 participants from the initial cohort were followed-up for a median of 5 years. Sera were collected between 2010 and 2011. Two-step screening was performed with standard serum electrophoresis followed by immunofixation and determination of the serum concentration of monoclonal-protein (M-protein). RESULTS: Of the 680 participants (21 with MGUS), 348 (51%) agreed to participate in the follow-up study and 10 were found to have MGUS. Among the 21 MGUS patients initially identified, nine were followed-up, six had persistent M-protein, and one patient had progressed to multiple myeloma (progression rate, 1.0%/yr). The M-protein disappeared in the remaining two individuals. Among the 339 participants without MGUS who were followed-up, four developed an M-protein. There was no significant difference in survival with respect to the presence of MGUS (p=0.66). CONCLUSION: The 5-year follow-up data show that the natural clinical course of MGUS in Korea is similar to that in Western countries. MGUS was not associated with an increased risk of death over the 5-year study period.
