A case of pineal germioma presenting with diabetes insipidus.
- Author:
Sam Seok PARK
1
;
Young Keun CHOI
;
Woo Hyung BAE
;
Seok Man SON
;
In Ju KIM
;
Yog Ki KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Case Report
- Keywords:
Pinealoma;
Germinoma;
Diabetes insipidus;
Neurogenic
- MeSH:
Adult;
Biopsy;
Brain;
Diabetes Insipidus*;
Diabetes Insipidus, Neurogenic;
Diplopia;
Drug Therapy;
Etoposide;
Follow-Up Studies;
Germinoma;
Headache;
Humans;
Magnetic Resonance Imaging;
Male;
Osmolar Concentration;
Pineal Gland;
Pinealoma;
Pituitary Gland;
Polydipsia;
Polyuria;
Vasopressins;
Visual Acuity;
Vomiting;
Water Deprivation
- From:Korean Journal of Medicine
2000;59(3):305-309
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Central diabetes insipidus caused by pineal gland neoplasm is rare. Here, we describe a case of central diabetes insipidus and pineal germinoma with seeding to pituitary stalk along CSF pathway. A 27 year-old male patient was admitted due to polyuria, polydipsia, headache, vomiting, diplopia, and decreased visual acuity for recent two months. Urine osmolality measured after water deprivation was below 100mOsm/kg. However, urine osmolality increasd above 300 mOsm/kg with pitressin administration. Brain MRI showed a 2cm sized mass with seeding into pituitary stalk along CSF in pineal region. Surgical biopsy revealed pineal germinoma. Two cycles of chemotherapy with etoposide and cis-platin were done followed by brain irradiation(2,500cGy). Follow up brain MRI after second chemotherapy showed complete remission. The patient had no neurologic and endocrinologic deficit after the treatment.
