Clinical Significance of Cone-shaped Epiphysis and Brachymesophalangia of the Fifth Middle Phalanx in Korean Children with Normal Short Stature.
- Author:
Yun Hye JUNG
1
;
Eun Jung CHOI
;
Im Jeong CHOI
;
Su Young HONG
;
Jae Ho YOO
Author Information
1. Department of Pediatrics, Maryknoll Medical Center, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Bone development;
Dysplasia;
Phalanges of fingers;
Hand radiography;
Body height
- MeSH:
Adult;
Body Height;
Bone Development;
Bone Morphogenetic Protein 5;
Child;
Epiphyses;
Female;
Finger Phalanges;
Fingers;
Humans;
Male;
Medical Records;
Retrospective Studies
- From:Journal of Korean Society of Pediatric Endocrinology
2009;14(1):45-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE:The cone-shaped epiphyses mid-5 (CSE-5) and brachymesophalagia-5 (BMP-5) are common osseous anomalies. Those are thought to be normal variants. We evaluated the frequency of CSE-5 and BMP-5 and the influence of them on adult height in Korean children with normal short stature. METHODS:We retrospectively reviewed medical records of 322 normal short stature children. Lengths of the fourth (MP-4) and fifth middle phalanx (MP-5) and widths of MP-5 of all children were measured. Two indicies for BMP-5 were used. Index 1 was based upon the ratio of the width to the length of the MP-5. Index 2 was based upon the ratio of the lengths of MP-5 to MP-4. CSE-5 was assessed by visual inspection only. We assessed several clinical parameters as follows; advanced skeletal maturation, z-scores of height, target height (THz) and predicted adult height (PAHz) according to CSE-5 and/or BMP-5. Results:Of the 322 children, 23.6% had BMP-5 (male 19.5%, female 27.4%), 23.6% had CSE-5 (male 13.0%, female 33.3%). The children with CSE-5 and/or BMP-5 were more advanced skeletal maturation than normal fifth finger (0.07+/-1.09 yrs vs -0.23+/-1.34 yrs, P=0.049), lower PAHz (-1.13+/-1.09 vs -0.71+/-1.28, P=0.008), lower PAHz- THz (-0.53+/-1.07 vs -0.14+/-1.30, P=0.013). In male subjects, the PAHz had weak correlation with index 1 (r=-0.26, P=0.001) and index 2 (r=0.27, P=0.001). CONCLUSION:This study suggests that BMP-5 and CSE-5 in Korean children with short stature are one contributable factor for adult height.
