Changes in Liver Stiffness after Acute or Chronic Liver Injury due to Viral Hepatitis - Does Fibrosis Exist after Recovery from Acute Viral Hepatitis?.
10.4166/kjg.2009.54.3.155
- Author:
Jeong Han KIM
1
;
Hyung Joon YIM
;
Seung Young KIM
;
Jae Hong AHN
;
Young Kul JUNG
;
Moon Kyung JOO
;
Su Hyun KIM
;
Ji Hoon KIM
;
Yeon Seok SEO
;
Jong Eun YEON
;
Hong Sik LEE
;
Soon Ho UM
;
Sang Woo LEE
;
Kwan Soo BYUN
;
Jae Hyun CHOI
;
Ho Sang RYU
Author Information
1. Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. gudwns21@medimail.co.kr
- Publication Type:Original Article ; Comparative Study ; English Abstract
- Keywords:
Transient elastography;
Liver stiffness;
Acute viral hepatitis;
Fibrosis
- MeSH:
Acute Disease;
Adolescent;
Adult;
Aged;
Alanine Transaminase/blood;
Bilirubin/analysis;
Carrier State;
Chronic Disease;
Elasticity;
Elasticity Imaging Techniques;
Female;
Hepatitis, Viral, Human/*complications/diagnosis;
Humans;
Liver/enzymology/*ultrasonography;
Liver Cirrhosis/*ultrasonography/*virology;
Male;
Middle Aged
- From:The Korean Journal of Gastroenterology
2009;54(3):155-161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Liver stiffness (LS) measurement by transient elastography can estimate the degrees of liver fibrosis in patients with chronic liver disease. However, longitudinal data of LS after recovery of acute viral hepatitis are still lacking. In the present study, we aimed to evaluate among LS of patients at various stages of viral hepatitis and normal control. METHODS: Patients who had admitted at Korea University Ansan Hospital between January 2006 and January 2007 due to acute viral hepatitis and recovered were recruited (group A, n=22). We compared the liver biochmistry and LS of group A with those of healthy control group (group B, n=23), current acute viral hepatitis group (group C, n=49), and chronic viral hepatitis group (group D, n=66). RESULTS: Mean ALT, total bilirubin, and LS level of group A were not different from group B (p=0.318, p=0.116, p=0.125, respectively). However, group A had lower ALT, total bilirubin, and LS values compared to group C (all p<0.001), and lower ALT and LS values compared to group D (p=0.007, p<0.001). The mean total bilirubin was not significantly different from group D (p=0.117). CONCLUSIONS: Our data suggest that liver fibrosis is a long-term sequela of chronic hepatitis, and not developed in patients who recovered from acute viral hepatitis.
