A Case of CD56+ Extranodal NK/T-cell Lymphoma, Nasal Type, Presenting as a Duodenal Ulcer Bleeding.
10.4166/kjg.2009.54.3.174
- Author:
Ji Hee YU
1
;
Kee Don CHOI
;
Young Wha KOH
;
Won Jung CHOI
;
Ho June SONG
;
Gin Hyug LEE
;
Hwoon Yong JUNG
;
Jin Ho KIM
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. keedon@amc.seoul.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
NK/T-cell lymphoma;
Duodenum;
Bleeding
- MeSH:
Antigens, CD3/metabolism;
Antigens, CD56/*metabolism;
Bone Marrow/pathology;
Duodenal Ulcer/*diagnosis;
Herpesvirus 4, Human/genetics/metabolism;
Humans;
Lymphoma, Extranodal NK-T-Cell/*diagnosis/pathology;
Male;
Middle Aged;
Peptic Ulcer Hemorrhage/*diagnosis;
Tomography, X-Ray Computed
- From:The Korean Journal of Gastroenterology
2009;54(3):174-179
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Extranodal NK/T-cell lymphoma is a recently recognized distinct entity within the World Health Organization classification of lymphoid tumors. It is relatively prevalent in Asian and South American populations. It most commonly occurs in the nasal or paranasal areas and less frequently in the skin, the soft tissue, and the gastrointestinal tract. Among these, extranodal NK/T-cell lymphoma of the gastrointestinal tract has shown an aggressive clinical course. We report a case of CD56+ extranodal NK/T-cell lymphoma presenting as a duodenal ulcer bleeding. A 62-year-old male patient presented with melena and abdominal pain. Endoscopic examination of the upper gastrointestinal tract showed the duodenal ulcer covered by blood clot. Pathologic examination revealed the diffuse infiltration of atypical lymphocytes with an angiocentric growth pattern, which was positive for CD3, CD56, and granzyme. The patient showed rapid deteriorating clinical course and died on day 14 after admission. Thus, we report this case with the review of literatures.
