A Case of Immune Thrombocytopenic Purpura Accompanying Ulcerative Colitis.
10.4166/kjg.2014.64.4.234
- Author:
Hyun Tae KIM
1
;
Tae Oh KIM
;
Hyung Jun KIM
;
Soon Il LEE
;
Gi Jung JEON
;
Eun Ji LEE
;
Seunghyun PARK
;
Taehoon NO
Author Information
1. Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. kto0440@paik.ac.kr
- Publication Type:Case Report
- Keywords:
Ulcerative colitis;
Immune thrombocytopenic purpura;
Immunoglobulin
- MeSH:
Autoimmunity;
Blood Platelets;
Bone Marrow;
Colitis, Ulcerative*;
Colon;
Gastrointestinal Hemorrhage;
Humans;
Immunization, Passive;
Immunoglobulins;
Membranes;
Platelet Count;
Purpura, Thrombocytopenic, Idiopathic*;
Splenomegaly;
Thrombocytopenia;
Young Adult
- From:The Korean Journal of Gastroenterology
2014;64(4):234-238
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of the colon with a variable clinical course of exacerbation and remission. Extraintestinal manifestations of UC, including hematological disorders, such as the rare immune thrombocytopenic purpura (ITP), may be the presenting symptoms. We encountered the case of a 23-year-old man with UC who showed typical symptoms and endoscopic findings. Despite receiving steroid treatment, the patient developed severe thrombocytopenia. He was diagnosed with ITP, characterized by autoimmunity, a demonstrated low platelet count, normal bone marrow, positivity for autoantibody to platelet membrane antigen, and no splenomegaly. We initiated high dose intravenous immunoglobulin immediately for treatment of his steroid-refractory thrombocytopenia. The patient's hematochezia and platelet count improved following immunoglobulin treatment. After discharge, the patient's platelet count was maintained at a stable level and his condition was good. This case suggests that immunoglobulin therapy may be useful for treatment of ITP in UC.
