Reduction of Continuous Theta Burst Stimulation-Induced Motor Plasticity in Healthy Elderly With COMT Val158Met Polymorphism.
10.5535/arm.2014.38.5.658
- Author:
Nam Jae LEE
1
;
Hyun Jung AHN
;
Kwang Ik JUNG
;
Suk Hoon OHN
;
Jeonghoon HONG
;
Yun Joong KIM
;
Woo Kyoung YOO
Author Information
1. Department of Physical Medicine and Rehabilitation, Hallym University College of Medicine, Chooncheon, Korea. wooky@hallym.or.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Transcranial Magnetic Stimulation;
Catechol-O-methyltransferase;
Neuronal plasticity;
Genetic polymorphism;
Motor cortex
- MeSH:
Adult;
Aged*;
Catechol O-Methyltransferase;
Evoked Potentials, Motor;
Female;
Humans;
Motor Cortex;
Neuronal Plasticity;
Plastics*;
Polymorphism, Genetic;
Transcranial Magnetic Stimulation;
Volunteers
- From:Annals of Rehabilitation Medicine
2014;38(5):658-664
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To delineate whether cortical plasticity induced by continuous theta burst stimulation (cTBS) differed according to catechol-O-methyltransferase (COMT) gene polymorphism in healthy older adults. METHODS: Eighteen healthy older volunteers (mean age 73.78+/-5.04; 12 females and 6 males) were recruited. Volunteers randomly assigned in either a sham-first or real cTBS first group participated in two separate TMS visits with at least a 2-day wash-out period. Genotyping was carried out at baseline by a separate researcher who was blinded. cTBS was delivered in a hot spot over M1 at an active motor threshold of 80%. Motor evoked potentials (MEPs) were obtained at 120% of the resting motor threshold before and after sham/cTBS. RESULTS: The relative MEP to baseline was significantly decreased 0 and 10 minutes post-stimulation and increased 40 minutes post-stimulation, as compared with the sham condition. Immediately after cTBS, the Val/Val group had a significantly reduced relative MEP value, as compared with the MET carrier group. CONCLUSION: In healthy older persons, cTBS-induced motor plasticity was reduced in the COMT Val/Val group as compared with the 158Met carrier group.
