Analgesic Effect of Intrathecal Gabapentin in a Rat Model of Persistent Muscle Pain.
10.5535/arm.2014.38.5.682
- Author:
Tae Wook KANG
1
;
Min Kyun SOHN
;
Noh Kyoung PARK
;
Sang Hyung KO
;
Kyoung Jin CHO
;
Jaewon BEOM
;
Sangkuk KANG
Author Information
1. Department of Physical Medicine and Rehabilitation, Sun General Hospital, Daejeon, Korea. rmactksk@daum.net
- Publication Type:Original Article
- Keywords:
Analgesic effect;
Intrathecal gabapentin injection;
Persistent muscle pain
- MeSH:
Animals;
Catheters;
Central Nervous System;
Humans;
Hyperalgesia;
Injections, Intramuscular;
Models, Animal*;
Muscle, Skeletal;
Myalgia*;
Rats
- From:Annals of Rehabilitation Medicine
2014;38(5):682-688
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the analgesic effect of intrathecal gabapentin therapy on secondary hyperalgesia in a rat model of persistent muscle pain. METHODS: Intrathecal catheters were implanted into rats. Mechanical secondary hyperalgesia was induced by repeated intramuscular injections of acidic solution into the gastrocnemius muscle. Gabapentin was administrated intrathecally. Rats were allocated to control and experimental (gabapentin 30, 100, 300, and 1,000 microg) group. After gabapentin administration, mechanical withdrawal threshold was measured every 15 minutes and the motor function was measured 30 minutes later. RESULTS: Mechanical hyperalgesia was evoked after the second acidic buffer injection. There was a significant improvement on the mechanical threshold after administration of 100, 300, and 1,000 microg gabapentin compared to pre-injection and the control group. The analgesic effect continued for 105, 135, and 210 minutes, respectively. To discern side effects, motor function was measured. Motor function was preserved in both groups after gabapentin administration, except for rats who received 1,000 microg gabapentin. CONCLUSION: Intrathecal gabapentin administration produces dose-dependent improvements in mechanical hyperalgesia in a persistent muscle pain rat model. This implicates the central nervous system as having a strong influence on the development of persistent mechanical hyperalgesia. These results are helpful in understanding the pathophysiology of secondary hyperalgesia and in the treatment of patients with chronic muscle pain.
