Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies.
10.4111/kju.2015.56.11.785
- Author:
Arturo DOMINGUEZ
1
;
Miquel BAYO
;
Jesus MUNOZ-RODRIGUEZ
;
Jose Antonio BELLIDO
;
Jose Maria ABASCAL-JUNQUERA
;
Naim HANNAOUI
;
Josep Maria BANUS
Author Information
1. Urology Department, Institut Catala dUrologia i Nefrologia, Barcelona, Spain. arturodom1980@hotmail.com
- Publication Type:Case Reports
- Keywords:
Analysis;
Diagnosis;
Heterophile antibodies;
Immunoassay;
Prostate-specific antigen
- MeSH:
Antibodies, Heterophile/*immunology;
False Positive Reactions;
Humans;
Luminescence;
Male;
Middle Aged;
Prostate-Specific Antigen/*blood;
Prostatic Neoplasms/blood/*diagnosis/immunology
- From:Korean Journal of Urology
2015;56(11):785-787
- CountryRepublic of Korea
- Language:English
-
Abstract:
Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.
