Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B.
- Author:
Seok Yong AHN
1
;
Long Quan PI
;
Sungjoo Tommy HWANG
;
Won Soo LEE
Author Information
- Publication Type:Original Article
- Keywords: Hair growth; IGF-I; PDGF-A; PDGF-B
- MeSH: Apoptosis; Cytokines; Hair; Hair Follicle; Humans; Insulin; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Organ Culture Techniques; Platelet-Derived Growth Factor; Polymerase Chain Reaction; Reverse Transcription; RNA, Messenger; Up-Regulation
- From:Annals of Dermatology 2012;24(1):26-31
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Insulin-like growth factor-I (IGF-I) shares a high degree of structural and functional homology with insulin and is a potent mitogen supporting cell growth and survival in many kinds of the tissues and cells. It also plays a role in some differentiation and anti-apoptotic functions. In previous reports, it has been shown that IGF-I stimulates hair follicle (HF) growth, maintains the anagen stage, and postpones the catagen stage. OBJECTIVE: The exact mechanism of the effect of IGF-I on HF growth is not yet established. Therefore, we investigated the relationships between IGF-I and various other factors (i.e. apoptosis related molecules, pro-inflammatory cytokines, other growth factors, etc.) in the control of HF growth. METHODS: The effect of IGF-I on human hair growth was measured using an organ culture model of human HFs and compared with a control group that did not receive IGF-I. We also measured mRNA expression of factors related to hair growth and apoptosis (which was determined by reverse transcription polymerase chain reaction (RT-PCR). RT-PCR was done on days 2, 4, 6, and 8 of organ culture. RESULTS: In organ cultured human hair follicles, IGF-I had a positive effect on the rate of linear hair growth. IGF-I maintained the anagen phase. IGF-I increased the expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the expression ratio of Bcl-2/Bax. CONCLUSION: The effect of IGF-I on hair growth appears to be related to the upregulation of PDGF-A and PDGF-B and to the anti-apoptotic effect of IGF-I.
