Outcome of Postoperative Intratumoral Bleomycin Injection for Cystic Craniopharyngioma.
10.3346/jkms.2002.17.2.254
- Author:
Dong Hyuk PARK
1
;
Jung Yul PARK
;
Joo Han KIM
;
Yong Gu CHUNG
;
Hoon Kap LEE
;
Ki Chan LEE
;
Jung Keun SUH
Author Information
1. Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea. jypark@kumc.or.kr
- Publication Type:Original Article
- Keywords:
Craniopharyngioma;
Bleomycin;
Cysts;
Lactate Dehydrogenase
- MeSH:
Adolescent;
Adult;
Aged;
Antibiotics, Antineoplastic/administration & dosage/adverse effects/*therapeutic use;
Bleomycin/administration & dosage/adverse effects/*therapeutic use;
Brain/radiation effects;
Child;
Child, Preschool;
Craniopharyngioma/*drug therapy/radiography/surgery;
Female;
Follow-Up Studies;
Humans;
Injections;
L-Lactate Dehydrogenase/metabolism;
Male;
Middle Aged;
Pituitary Neoplasms/*drug therapy/radiography/surgery;
*Postoperative Care;
Retrospective Studies;
Tomography, X-Ray Computed/methods
- From:Journal of Korean Medical Science
2002;17(2):254-259
- CountryRepublic of Korea
- Language:English
-
Abstract:
Total excision is a treatment of choice in preventing the relapse of craniopharyn-gioma, but for tumors involving an extensive area, it is often associated with an increased risk of complications. We have performed a partial or subtotal tumor removal followed by repeated injection of bleomycin into the remaining tumor through a subcutaneous reservoir as postoperative adjuvant therapy. A retro-spective review of clinical, radiological, and surgical data was performed for 10 patients (5 males and 5 females; age, 3-65 yr; follow-up duration, 12-79 months) with cystic craniopharyngiomas. The measurements of lactate dehydrogenase (LDH) level at each aspiration were performed. The shrinkage and/or stabiliza-tion of tumor was initially noted in all cases. The recurrence of tumor was seen in 4 cases (40%). The decreased or increased level of LDH was interpreted as tumor shrinkage or recurrence, respectively. The transient toxic reactions were observed in 3 patients (30%). Our study demonstrates that postoperative bleo-mycin injection for cystic craniopharyngioma, although does not appear to eradi-cate the tumor, decreases and stabilizes the tumor size, when used as an adju-vant therapy in young patients.
