Association of the Invasively Measured Aortic Stiffness and Coronary Artery Disease.
10.4070/kcj.2005.35.10.766
- Author:
Jin Shik PARK
1
;
Joung Joo SEO
;
Joong Wha CHUNG
;
Hyun Jai CHO
;
Jang Whan BAE
;
Kwang Il KIM
;
Hyun Jae KANG
;
Bon Kwon KOO
;
Tae Jin YEON
;
Yong Jin KIM
;
Hyo Soo KIM
;
Dae Won SOHN
;
Myoung Mook LEE
;
Young Bae PARK
;
Yun Shik CHOI
;
Byung Hee OH
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ohbhmed@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary artery disease;
Coronary restenosis;
Pulse wave velocity
- MeSH:
Atherosclerosis;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Restenosis;
Coronary Vessels*;
Drug-Eluting Stents;
Dyslipidemias;
Humans;
Hypertension;
Incidence;
Odds Ratio;
Perfusion;
Prospective Studies;
Pulse Wave Analysis;
Risk Factors;
Smoke;
Smoking;
Vascular Stiffness*
- From:Korean Circulation Journal
2005;35(10):766-772
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Aortic stiffness is believed to be an important risk factor of coronary artery atherosclerosis (CAA), as it directly affects coronary perfusion. The following aspects of the invasively measured aortic pulse wave velocity (PWV) were assessed in relation to CAA: The effect of cardiovascular risk factors on PWV, the effect of PWV on the severity of CAA and on the development of the restenosis after drug-eluting stent (DES) implantation. SUBJECTS AND METHODS: 371 subjects who had undergone coronary angiography were enrolled, with all undergoing an invasive aortic PWV measurement also. 112 patients, who had undergone a DES implantation, were prospectively investigated for the effect of PWV in relation to the subsequent risk of major adverse cardiac events (MACE). RESULTS: Among the conventional cardiovascular risk factors, an age >60 (10.79+/-4.92 vs. 8.35+/-4.02, p=0.0006), diabetes (10.97+/-4.66 vs. 9.26+/-4.70 m/sec, p=0.0118) and dyslipidemia (10.38+/-4.97 vs. 9.47+/-4.55m/sec, p=0.0421) were significantly associated with an increased PWV, but sex, smoking and hypertension were not associated with an increased PWV. The PWV was shown to be significantly associated with the severity of CAD. The odds ratio (OR) of 1m/sec increment in the PWV for an increased vessel score was 1.08 (95% confidence interval (CI): 1.03-1.13, p=0.0017). There were no differences in the incidence of MACE and the changes in the angiographic parameters between the high (>10 m/sec) and low PWV groups. CONCLUSION: The invasively measured aortic PWV was affected by age (>60), diabetes and dyslipidemia, and also showed a strong association with the severity of CAD. The aortic PWV was not a significant risk factor for restenosis following a DES implantation.
