The Efficacy of Vaccinium Uliginosum for Early Age-Related Macula Degeneration.
10.3341/jkos.2013.54.8.1255
- Author:
Hyun Kyung KIL
1
;
You Mi SONG
;
Koi CHUN
Author Information
1. Department of Ophthalmology, Daejin Medical Hospital, Seongnam, Korea. hk9111@dmc.or.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Age-related macular degeneration;
Bog bilberry;
IS/OS junction;
Optical coherence tomography
- MeSH:
Eye;
Glare;
Humans;
Intraocular Pressure;
Macular Degeneration;
Microscopy;
Tears;
Tomography, Optical Coherence;
Vaccinium;
Vaccinium myrtillus;
Visual Acuity;
Wetlands
- From:Journal of the Korean Ophthalmological Society
2013;54(8):1255-1260
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of Bog Bilberry (Vaccinium uliginosum) extract in eyes with early age-related macular degeneration (AMD). METHODS: Forty-four eyes of forty four patients with early AMD were included in this randomized, double-blinded, and placebo-controlled study. All participants were randomly assigned to either the placebo group (n = 24), or the bog bilberry extract group (n = 20). Before drug administration, an ophthalmic examination which included slit lamp microscopy, best corrected visual acuity, and intraocular pressure was performed, and repeated 1and 3 months after treatment. Objective scatter index, glare and tear film break-up time were checked by Optical Quality Analysis System (OQAS, Visiometrics, Spain) and drusen volume, central macular thickness, and RPE and IS/OS junction thickness were investigated with spectral-domain optical coherence tomography (Spectralis, Heidelberg, Germany). RESULTS: In the bog bilberry extract group, RPE and IS/OS junction thickness was significantly increased compared to the placebo group after 3 months of drug administration. CONCLUSIONS: Bog Bilberry extract may play a favorable role in preventing the atrophic change of RPE and IS/OS junction layer and the progression of early macular degeneration.
