Retinal Nerve Fiber Layer Defect Associated with Astrocytic Hamartoma in a Patient with Tuberous Sclerosis.
10.3341/jkos.2013.54.8.1282
- Author:
Ka Hyun LEE
1
;
Naeun LEE
;
Chang Kyu LEE
;
Sa Min HONG
;
Gong Je SEONG
;
Chan Yun KIM
Author Information
1. The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. kcyeye@yuhs.ac
- Publication Type:Case Report
- Keywords:
Astrocytic hamartoma;
Retinal nerve fiber layer defect;
Tuberous sclerosis
- MeSH:
Eye;
Follow-Up Studies;
Hamartoma;
Humans;
Nerve Fibers;
Optic Disk;
Optic Nerve;
Retina;
Retinaldehyde;
Tuberous Sclerosis;
Visual Fields
- From:Journal of the Korean Ophthalmological Society
2013;54(8):1282-1286
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report the progression of an astrocytic hamartoma of the right optic nerve head as well as the retina, and the progression of retinal nerve fiber defect associated with astrocytic hamartoma in a patient with tuberous sclerosis. CASE SUMMARY: A 6-year-old boy with tuberous sclerosis and an astrocytic hamartoma of the right optic nerve head, which was found at the time of ophthalmologie examinations, was referred from the pediatric neurologist for evaluation of the vigabatrin-associated visual field changes. Fundus examination revealed 1/2 disc diameter (DD)-sized astrocytic hamartoma located at the margin of the superior part of the optic nerve. The retina of the left eye was normal. Eighteen months after the first visit, enlarged optic disc hamartoma of the right eye and newly onset retinal astrocytic hamartoma located approximately 1.5 DD inferior to the fovea of the left eye were found. Three years later, an increase in the size of the astrocytic hamartoma of the right optic nerve and development of retinal nerve fiber defects were observed. CONCLUSIONS: Astrocytic hamartoma in patients with tuberous sclerosis is usually stable without progression. However, in our patient, astrocytic hamartoma showed progression, and development of retinal nerve fiber defects occurred. Regular follow-up is necessary for astrocytic hamartoma in patients with tuberous sclerosis.
