The effect of lymphadenectomy on the survival rate of clinical stage I endometrial cancer.
- Author:
Mee Won SEO
1
;
Hee Young LEE
;
Dae Yeon KIM
;
Dae Sik SUH
;
Jong Hyeok KIM
;
Yong Man KIM
;
Young Tak KIM
;
Joo Hyun NAM
Author Information
1. Department of Obstetric and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ytkim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Clinical stage I endometrial cancer;
Lymphadenectomy;
Survival rates
- MeSH:
Chungcheongnam-do;
Endometrial Neoplasms*;
Female;
Humans;
Hysterectomy;
Lymph Node Excision*;
Lymph Nodes;
Neoplasm Metastasis;
Retrospective Studies;
Survival Rate*
- From:Korean Journal of Gynecologic Oncology
2006;17(3):227-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluation of the effect of pelvic or paraaortic lymphadenectomy on survival rates in the management of clinical stage I endometrial cancer METHODS: A retrospective analysis was performed on a total 303 clinical stage I endometrial cancer patients from 1989 to 2004 at Asan Medical Center. Two hundred-sixty-three (86.8%) underwent a total hysterectomy and bilateral salpingo-oophorectomy with pelvic or paraaortic lymphadenectomy, while forty (13.2%) underwent a total hysterectomy and bilateral salpingo-oophorectomy only. Characteristics of patients and 5-year survival rate of each patients group were analyzed. RESULTS: Seventeen (6.5%) showed lymph node metastases and overall 5-year survival rate of clinical stage I endometrial cancer was 96.9%. The 5-year and 10-year survival rate of a group with lymphadenectomy were 96.4% and 86.6%, and those of a group without lymphadenectomy were 100% and 75.2%, respectively (p=0.48). The 5-year survival rate of a group with positive lymph nodes was 73.3%, that of a group with negative lymph nodes was 97.7% (p<0.05). CONCLUSION: The complete staging operation including lymphadenectomy did not improve the survival rates in a group with lymphadenectomy significantly. But the debates regarding the necessarity of lymphadenectomy in clinical stage I endometrial cancer still remains and a large randomized prospective study is needed.
