Rat Models for Ischemic Stroke.
10.5853/kjs.2011.13.3.107
- Author:
Hyun Young KIM
1
;
Seong Ho KOH
;
Seung Hyun KIM
Author Information
1. Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea. kimsh1@hanyang.ac.kr
- Publication Type:Review
- Keywords:
Ischemic stroke model;
Research;
Guideline
- MeSH:
Animals;
Rats;
Rodentia;
Stroke;
Virtues
- From:Korean Journal of Stroke
2011;13(3):107-113
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Highly reproducible and consistent ischemic stroke models are critical for obtaining more confident data. To date, the infarct variation of several ischemic rat models is considerable. Therefore, many factors related to outcome variation and infarct growth must be controlled. Among various infarct models of rodents, intraluminal filament model is common by virtue of its consistency of the success rate and the outcomes. Recently more long-term evaluation of functional and imaging outcomes is considered in terms of clinical practice. Concise and subsequent outcome assessment could result in the improvement of translational stroke research. We recommend that the researchers should remember the guidelines addressed by the Stroke Therapy Academic Industry Roundtable (STAIR) and the Good Laboratory Practice (GLP).
