A Case of Thrombotic Thrombocytopenic Purpura Associated with Ticlopidine.
- Author:
Myung Cheol BAE
1
;
Jang Wook KIM
;
Eun Ah JANG
;
Kyoon HUH
Author Information
1. Department of Neurology, Ajou University Hospital.
- Publication Type:Case Report
- Keywords:
Ticlopidine;
Purpura/Thrombotic thrombocytopenic
- MeSH:
Aged;
Diagnosis;
Dyspnea;
Female;
Humans;
Korea;
Plasma Exchange;
Platelet Count;
Purpura;
Purpura, Thrombotic Thrombocytopenic*;
Stroke;
Stupor;
Ticlopidine*
- From:Journal of the Korean Neurological Association
2000;18(4):512-514
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ticlopidine, a widely used antiplatelet agent, has been rarely reported to cause thrombotic thrombocytopenic purpura (TTP). To the best of our knowledge, its occurrence has never before been reported in Korea. A 69 years old female patient suffered from an acute ischemic stroke. Ticlopidine 250mg bid was started and she followed an uneventful clin-ical course. The platelet count was normal on the 1st and the 12th day of ticlopidine administration. Around the 31st day, at home, she developed purpura, dyspnea and a stuporous mental status. Under the diagnosis of TTP, a plasma exchange was performed and her condition eventually returned to the baseline status. Ticlopidine induced TTP can developed abruptly despite close monitoring of platelet count, as illustrated by this case. Physicians prescribing ticlopi-dine should be aware of this potentially dangerous complication.
