The Relationship between the p27 Expression of Papillary Thyroid Cancer Cells Obtained by FNA and Cervical Lymph Node Metastasis.
10.16956/kjes.2009.9.3.155
- Author:
Kwan Ju LEE
1
;
Jung Hea LEE
;
Jeong Soo KIM
;
Tai Gyu KIM
;
Sang Chul LEE
;
Jeong Goo KIM
;
Chang Joon AHN
;
Say June KIM
;
Dong Ho LEE
Author Information
1. Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea. dongho@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Papillary thyroid cancer;
Fine needle aspiration;
p27;
Lymph node metastasis
- MeSH:
Biopsy, Fine-Needle;
Breast Neoplasms;
Colorectal Neoplasms;
Genes, Tumor Suppressor;
Humans;
Lymph Node Excision;
Lymph Nodes*;
Neoplasm Metastasis*;
Stomach Neoplasms;
Thyroid Gland*;
Thyroid Neoplasms*;
Thyroidectomy
- From:Korean Journal of Endocrine Surgery
2009;9(3):155-160
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The p27 gene as a tumor suppressor gene is associated with colorectal cancer, gastric cancer and breast cancer. Some studies have shown a relationship between the underexpression of p27 and lymph node metastasis in papillary thyroid carcinoma. The aim of this study is to evaluate the relationship between a p27 expression of the papillary thyroid cancer cells obtained by fine needle aspiration (FNA) and cervical lymph node metastasis. METHODS: This study included 60 patients with papillary thyroid cancer and who underwent total thyroidectomy or lobectomy. Central lymph node dissection was routinely done. Out of these patients, 30 patients underwent a FNA procedure during the operation. Immunohistochemical staining for p27 antibody was performed on the papillary thyroid cancer tissues and cells. RESULTS: Cervical lymph node metastasis is correlated with the tumor size and lymphovascular invasion (P<0.001). The underexpression of p27 for the papillary thyroid cancer tissues and cells was associated with lymph node metastasis (P=0.009). CONCLUSION: An evaluation of the p27 expression for the papillary thyroid cancer cells obtained by FNA may be useful as a predictor for lymph node metastasis before surgery.
