A case of TSH-secreting pituitary adenoma with acromegaly.
- Author:
Yu Jin HAH
1
;
Mi Kyung KIM
;
Hye Soon KIM
;
Ealmaan KIM
;
Man Bin YIM
;
Misun CHOE
;
Keun Gyu PARK
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. kgpark@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Thyrotrophs;
Pituitary neoplasm;
Acromegaly
- MeSH:
Acromegaly;
Cytoplasm;
Diabetes Mellitus;
Glucose;
Growth Hormone;
Humans;
Insulin-Like Growth Factor I;
Male;
Middle Aged;
Pituitary Gland;
Pituitary Neoplasms;
Thyrotoxicosis;
Thyrotrophs;
Thyrotropin
- From:Korean Journal of Medicine
2009;77(Suppl 1):S97-S102
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Growth hormone (GH) and thyrotropin (TSH)-secreting pituitary adenomas are very rare and account for only 0.5% of all pituitary adenomas. We report a case of a GH/TSH-secreting pituitary adenoma in a 53-year-old male patient. He presented with symptoms of thyrotoxicosis, clinical features of acromegaly, and diabetes mellitus. The laboratory examinations showed high serum levels of free T4, TSH, and free alpha-subunit. Additionally, serum levels of GH and insulin-like growth factor (IGF-1) wereincreased. GH was not suppressed below 1 microgram/L by an oral 75 g glucose loading test, and TSH was not stimulated by thyrotropin- releasing hormone. A sellar MRI showed a large lobulated mass on the pituitary gland, so transcranial surgery was performed. Immunohistochemical staining showed anti-GH and anti-TSH positive tumor cells in the cytoplasm. Serum GH, IGF-1, free T4, and TSH levels normalized after surgery.
