Rhabdoid Colorectal Carcinomas: Reports of Two Cases.
- Author:
Sang Hwa LEE
1
;
Hyesil SEOL
;
Wook Youn KIM
;
So Dug LIM
;
Wan Seop KIM
;
Tae Sook HWANG
;
Hye Seung HAN
Author Information
1. Department of Pathology, Research Center, Aerospace Medical Center, Republic of Korea Air Force, Cheongju, Korea.
- Publication Type:Case Report
- Keywords:
Adenocarcinoma;
Colon;
Rectum;
Rhabdoid tumor
- MeSH:
Adenocarcinoma;
Colon;
Colon, Sigmoid;
Colorectal Neoplasms;
Desmin;
Female;
Humans;
Keratins;
Lymph Nodes;
Neoplasm Metastasis;
Rectum;
Rhabdoid Tumor;
Vimentin
- From:Korean Journal of Pathology
2013;47(4):372-377
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rhabdoid colorectal carcinomas are very rare and only 10 cases have been previously reported. We report two cases of rhabdoid colorectal carcinoma, one arising in the sigmoid colon of a 62-year-old man and another in the rectum of an 83-year-old woman. In both cases, the patients had advanced tumors with lymph node metastases. The tumors mostly showed a diffuse arrangement with rhabdoid features and small glandular regions were combined. Transitional areas from the adenocarcinomas to the rhabdoid tumors were also noted. Adenocarcinoma cells were positive for mixed cytokeratin (CK), CK20 and epithelial membranous antigen (EMA), but focal positive for vimentin. The rhabdoid tumor cells were positive for mixed CK, but focal positive or negative for CK20 and EMA. In addition, they were diffusely positive for vimentin, but negative for desmin. The histological and immunohistologial findings of these two cases suggest that the rhabodid tumor cells originated from dedifferentiated adenocarcinomas.
