Sebaceous Carcinoma Arising in Mature Cystic Teratoma of Ovary.
- Author:
Hyo Jeong AN
1
;
Yong Han JUNG
;
Hye Kyoung YOON
;
Soo Jin JUNG
Author Information
1. Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. soojinmd@hanmail.net
- Publication Type:Case Report
- Keywords:
Sebaceous carcinoma;
Sebaceous adenoma;
Mature cystic teratoma;
Ovary
- MeSH:
Basophils;
Carcinoembryonic Antigen;
Female;
Hair;
Humans;
Hysterectomy;
Keratin-19;
Keratin-7;
Keratins;
Molecular Weight;
Mucin-1;
Ovary;
Pelvic Pain;
Teratoma
- From:Korean Journal of Pathology
2013;47(4):383-387
- CountryRepublic of Korea
- Language:English
-
Abstract:
Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.
