Detection of Epidermal Growth Factor Receptor mRNA by in Situ Hybridization in Cataractous Lens Epithelium.
- Author:
Jong Chan KIM
1
;
Gye Jong BAE
;
Jae Ho KIM
Author Information
1. Department of Ophthalmology, Our Lady of Mercy Hospital, Catholic University, Medical College, Inchon, Korea.
- Publication Type:Original Article
- Keywords:
Epidermal growth facter;
Epidermal growth facter recepter;
In situ hybridization;
Cataractous lens epithelium
- MeSH:
Cataract*;
Diabetes Mellitus;
Epidermal Growth Factor*;
Epithelium*;
In Situ Hybridization*;
Receptor, Epidermal Growth Factor*
- From:Journal of the Korean Ophthalmological Society
1995;36(12):2121-2128
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In this study, we investigated the correlation between the expression of EGFR-mRNA in situ hybridization method and the clinical feature of the cataract. The results were as followed. Nineteen out of fourty six cases(41.3%) were showed the expression of EGFRmRNA in lens epithelium. No correlation between the age of the lenses and the expression of EGFR-mRNA could be demonstrated. The expression of EGFR-mRNA in lens epithelium correlated significantly (P<0.01) with the clinical stage of the cataract. No correlation between the diabetes mellitus and the expression of EGFRmRNA could be demonstated. These results suggest that the EGFR-mRNA status in lens epithelium could be important for the development of the cataract.
