The Effect of Diphenylhydantoin on the Action of Ouabain.
10.4070/kcj.1971.1.2.23
- Author:
Sung Kyew KANG
;
Ok Kyu PARK
- Publication Type:Original Article
- MeSH:
Lethal Dose 50;
Ouabain*;
Phenytoin*
- From:Korean Circulation Journal
1971;1(2):23-26
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of diphenylhydantoin on LD 50 of ouabain was investigated in frogs, using "one hour frog method". LD50 of ouabain in control group was 1.90 microg/10g. A dose of 100 microg/10g diphenylhydantion did not affect the systemic manifestations of the frogs, but increase the LD50 of ouabain to 2.60 microg/10g. The difference of LD50 of ouabain and potency ratio between control group and diphenylhydantoin-treated group was statistically significant.
