Propranolol Hcl in Patients with Angina Pectoris.
10.4070/kcj.1971.1.2.43
- Author:
Jung Don SEO
;
Chan Sung CHO
;
Young Woo LEE
;
Kwang Hoi KIM
;
Do Jin KIM
;
Sung Ho LEE
- Publication Type:Original Article
- MeSH:
Angina Pectoris*;
Bradycardia;
Exercise Tolerance;
Humans;
Nausea;
Nitroglycerin;
Propranolol*;
Vomiting
- From:Korean Circulation Journal
1971;1(2):43-48
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A double-blind trial of the efficacy of propranolol hydrochloride a new beta adrenergic blocking agent, in the prophylactic treatment of angina pectoris was conducted in 9 patients. Through the trial period of 8 weeks to more than 26 weeks, the patients received propranolol and placebo for equal period. Following are the results. 1. The effective dose of propranolol hydrochloride in the prophylactic treatment of angina pectoris was 80 mg to 120 mg per day. 2. The effectiveness of propranolol hydrochloride was manifested by a reduction in frequency of pain to 40.7%, in nitroglycerin comsumption to 38.8% and by an increase in exercise tolerance. 3. Obseved side effects were transient nausea, vomiting and bradycardia, which were improved with reduction in drug dosage. 4. Further clinical and experimental information may be necessary in order to assess the long-term effects of propranolol hydrochloride.
