Influence of Toxoplasma gondii Acute Infection on Cholinesterase Activities of Wistar Rats.
10.3347/kjp.2013.51.4.421
- Author:
Alexandre Alberto TONIN
1
;
Aleksandro Schafer DA SILVA
;
Maria Luiza THORSTENBERG
;
Livia Gelain CASTILHOS
;
Raqueli Teresinha FRANCA
;
Daniela Bitencourt Rosa LEAL
;
Marta Maria Medeiros Frescura DUARTE
;
Fernanda Silveira Flores VOGEL
;
Mario Luiz DE LA RUE
;
Sonia Terezinha DOS ANJOS LOPES
Author Information
1. Department of Small Animal, Universidade Federal de Santa Maria, Brazil. tonin.aat@gmail.com
- Publication Type:Original Article ; Comparative Study
- Keywords:
Toxoplasma gondii;
acute toxoplasmosis;
acetylcholinesterase (AchE);
butyrylcholinesterase (BchE)
- MeSH:
Acetylcholinesterase/blood/*metabolism;
Animals;
Butyrylcholinesterase/blood/*metabolism;
Humans;
Lymphocytes/enzymology/parasitology;
Male;
Rats;
Rats, Wistar;
Toxoplasma/*physiology;
Toxoplasmosis/*enzymology/genetics/parasitology
- From:The Korean Journal of Parasitology
2013;51(4):421-426
- CountryRepublic of Korea
- Language:English
-
Abstract:
Several studies have shown the mechanisms and importance of immune responses against Toxoplasma gondii infection and the notable role of cholinesterases in inflammatory reactions. However, the association between those factors has not yet been investigated. Therefore, the aim of this study was to evaluate the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection. For that, an in vivo study was performed with evaluations of AChE and BChE activities on days 5 and 10 post-infection (PI). The activity of AChE in blood was increased on day 5 PI, while in lymphocytes its activity was enhanced on days 5 and 10 PI (P<0.05). No significant difference was observed between groups regarding to the activity of BChE in serum. A positive (P<0.01) correlation was observed between AChE activity and number of lymphocytes. The role of AChE as an inflammatory marker is well known in different pathologies; thus, our results lead to the hypothesis that AChE has an important role in modulation of early immune responses against T. gondii infection.
