The Effects of Anticholinesterase Drugs on Gastric Motility.
10.12701/yujm.1999.16.2.318
- Author:
Hyoung Chul CHOI
1
;
Jong Ho KIM
;
Jeoung Hee HA
;
Kwang Yoon LEE
;
Won Joon KIM
;
Dong Suk KWAK
;
Sung Hee KIM
;
Phil Hyun SONG
;
Ji Hyun YEO
Author Information
1. Department of Pharmacology College of Medicine, Yeungnam University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Anticholinesterase drug;
Ethanol;
Gastric motility
- MeSH:
Acetaldehyde;
Cholinesterase Inhibitors*;
Cholinesterases;
Ethanol;
Fenthion;
Muscle, Smooth;
Physostigmine;
Receptors, Cholinergic;
Relaxation;
Stomach;
Transducers
- From:Yeungnam University Journal of Medicine
1999;16(2):318-325
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Anticholinesterase drug inhibits acetylcholinesterase(AChE), induce accumulation of acetylcholine(ACh) near cholinergic receptors and cholinergic stimulation. This experiment was performed to study the effects of anticholinesterase drugs on gastric motility and the effect of ethanal on anticholinesterase drug-induced motility change. MATERIALS AND METHODS: After excision of stomach, 2x10mm circular musele strips were made, which were then fixed to the isolated muscle chamber. An isometric tension transducer was used to measure the contraction change of the gastric smooth muscle strips after drug addition. RESULTS: Fenthion, and irreversible anticholinesterase drug, increased ACh induced contraction of gastric smooth muscle strips and PAM, a cholinesterase activator, antagnized this action. Physostigmine, a reversible anticholinesterase drug, also increased the ACh induced contraction. The gastric motility was decreased by PAM. Ethanol, which is known to induce smooth muscle relaxation, inhibited the increase of contraction by fenthion. CONCLUSION: These results indicate that irreversible and reversible anticholinesterase drugs increase gastric motility and antagonized by cholinesterase activating drugs. And when exposed to both ethanol and anticholinesterase drug, gastric motility was decreased by the smooth muscle relaxation effect by ethanal.
