A Patient with RhD(el) (1227G>A) Failed to Produce Detectable Anti-D after Transfusion of RhD Positive Red Blood Cells.
- Author:
Ji Young PARK
1
;
Duck CHO
;
Hyun Woo CHOI
;
Mee Juhng JEON
;
Man Seok PARK
;
Jeong Won SONG
;
Myung Geun SHIN
;
Jong Hee SHIN
;
Soon Pal SUH
;
Dong Wook RYANG
Author Information
1. Department of Laboratory Medicine, Chonnam National University Medical School, Korea. hasomii@hanmail.net
- Publication Type:Case Report
- Keywords:
Del;
Anti-D;
RhD- recipient;
RhD+ blood
- MeSH:
Aged;
Agglutination;
Emergencies;
Erythrocytes*;
Humans;
Korea;
Tissue Donors
- From:Korean Journal of Blood Transfusion
2006;17(2):153-158
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Only 0.15% of all donors in Korea are RhD negative, which has led to a chronic shortage of RhD negative blood. Most physicians are aware of the potential for RhD alloimmunization after transfusing RhD+ red blood cells into RhD- patients. Hence, the undertransfusion of RhD- patients might be occurring in Korea. A 66-year-old man without a history of transfusion tested negative for anti-D in his serum. In an emergency situation where RhD- blood was unavailable, the patient received two units of RhD+ RBCs. Anti-D was not detected over three months after the transfusion. The red cells of the patient showed no agglutination with the anti-D reagent and a negative result by the standard weak D test. The polymerase chain reaction-sequence specific primers (PCR-SSP) and sequencing revealed D(el) (1227G>A) in the patient.
